Malaria caused by Plasmodium falciparum is responsible for approximately 80% of the incidence and 90% of deaths which occur\nin the World Health Organization (WHO) African region, with children and pregnant women having the highest incidence. P.\nfalciparumhas developed resistance, and therefore neweffective candidate antimalarial drugs need to be developed. Previous studies\nidentified 3,5-diaryl-2-aminopyridines as potential antimalarial drug candidates; therefore, derivatives of these compounds were\nsynthesized in order to improve their desired properties and pharmacokinetic (PK) properties of the derivatives were investigated\nin a mouse model which was dosed orally and intravenously. Collected blood samples were analyzed using liquid chromatography\ncoupled to mass spectrometer (LC-MS/MS). The mean peak plasma level of 1.9 ????M was obtained at 1 hour for compound 1 and\n3.3 ????Mat 0.5 hours for compound 2. A decline in concentration was observed with a half-life of 2.53 and 0.87 hours for compound\n1 in mice dosed orally and intravenously, respectively. For compound 2 a half-life of 2.96 and 0.68 hours was recorded. The\nbioavailability was 69% and 59.7% for compound 1 and compound 2, respectively.
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